ABSTRACT
We aimed to investigate the role of polymorphisms in IL-16 genes on the susceptibility of Coronary Artery Disease [CAD]. A total of 260 CAD cases and 281 health controls were collected between January 2008 and November 2011. Genotyping of IL-16 rs8034928, rs3848180, rs1131445, rs4778889 and rs11556218 was conducted by polymerase chain reaction [PCR] and matrix-assisted laser desorption/ionization time-of-flight [MALDI-TOF] mass spectrometry technologies. The frequencies of rs8034928 C allele and rs3848180 G allele in the CAD cases in CAD group were significantly higher than in controls. Compared with rs8034928 T/T genotype, a significant higher risk of CAD was found in C/C genotype [OR=1.87, 95%CI=1.17-3.03], and variant of rs8034928 showed a significant increased risk of CAD in dominant [OR=1.48, 95%CI=1.04-2.10] and recessive model [OR=1.70, 95%CI=1.10-2.67]. The rs3848180 G/G was found to be associated with risk of CAD [OR=1.79, 95%CI=1.16-2.75], and G allele carries had a significant risk of CAD [OR=1.47, 95%CI=1.02-2.13]. Our study indicated that rs8034928 and rs11556218 polymorphisms are associated with CAD risk in a Chinese population, and IL-16 gene polymorphisms may be used as a predictor to the susceptibility of CAD